National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, PR China.
Antiviral Res. 2011 Mar;89(3):189-92. doi: 10.1016/j.antiviral.2011.01.001. Epub 2011 Jan 15.
Certain host genetic polymorphisms in human leukocyte antigen (HLA) genes are reported to be associated with response to interferon α (IFNα) therapy. Two hundred and eighteen IFNα treatment-naïve chronic hepatitis B (CHB) patients were enrolled in the present study. HLA-A, B, C and DQA1, DQB1, DRB1 gene alleles were detected by polymerase chain reaction-sequencing based typing (PCR-SBT) and PCR-sequence specific primer (PCR-SSP), respectively. Frequencies of HLA-DQB10303 and DRB108 in response group were clearly lower than those in nonresponse group (P=0.019, OR=1.81, 95%CI=1.07-3.15; P=0.031, OR=2.43, 95%CI=1.02-5.98, respectively). Frequencies of haplotype *1101-*4601-*0102 (HLA-A, B, C) and haplotype *0302-0303-09 (HLA-DQA1, DQB1, DRB1) were clearly lower than those in nonresponse group (P=0.009, OR=4.84, 95%CI=1.29-19.48; P=0.031, OR=1.94, 95%CI=1.01-3.73, respectively). These results suggest that patients with HLA-DQB10303 or DRB108 alleles, and haplotype *1101-*4601-*0102 (HLA-A, B, C) or haplotype *0302-*0303-*09 (HLA-DQA1, DQB1, DRB1), might be less responsive to IFNα treatment.
某些人类白细胞抗原（HLA）基因中的宿主遗传多态性被报道与干扰素α（IFNα）治疗反应相关。本研究纳入了 218 例 IFNα 治疗初治的慢性乙型肝炎（CHB）患者。通过聚合酶链反应-测序基于分型（PCR-SBT）和聚合酶链反应-序列特异性引物（PCR-SSP）分别检测 HLA-A、B、C 和 DQA1、DQB1、DRB1 基因等位基因。应答组中 HLA-DQB10303 和 DRB108 的频率明显低于无应答组（P=0.019，OR=1.81，95%CI=1.07-3.15；P=0.031，OR=2.43，95%CI=1.02-5.98）。HLA-A、B、C 单体型*1101-4601-0102 和 HLA-DQA1、DQB1、DRB1 单体型0302-0303-09 的频率明显低于无应答组（P=0.009，OR=4.84，95%CI=1.29-19.48；P=0.031，OR=1.94，95%CI=1.01-3.73）。这些结果表明，具有 HLA-DQB10303 或 DRB108 等位基因，以及单体型1101-*4601-0102（HLA-A、B、C）或单体型0302-*0303-*09（HLA-DQA1、DQB1、DRB1）的患者对 IFNα 治疗的反应可能较低。
