Johnston James, King Christy M, Shanks Sky, Khademi Saieh, Nelson Joseph, Yu Jenny, Barbosa Peter
California School of Podiatric Medicine, Samuel Merritt University, Oakland, CA 94609, USA.
J Am Podiatr Med Assoc. 2011 Jan-Feb;101(1):35-40. doi: 10.7547/1010035.
since the implementation of highly active antiretroviral therapy (HAART), the life expectancy of patients with human immunodeficiency virus (HIV) has significantly increased. This is likely to cause changes in podiatric medical manifestations, such as plantar verrucae, in this population.
attendees at a San Francisco street fair in 2008 provided information about HIV status and the presence of verrucae via a survey. A total of 504 surveys were analyzed and compared with 1995 data, before HAART implementation. We examined if there was a statistically significant change in the increased likelihood of plantar verrucae in HIV-positive patients from 1995 to 2008. Then we examined the likelihood of HIV-positive patients (compared to HIV-negative patients) presenting with plantar verrucae in 2008, by using logistic regression, and controlling for age, sex, and race/ethnicity.
patients with HIV infection were 5.2 times more likely to present with plantar verrucae compared to patients without HIV infection in 2008 (95% confidence interval, 2.5-11.0, P < .0001) and 10.0 times more likely in 1995 (95% confidence interval, 3.4-29.0, P < .0001). This decrease in likelihood over time was not statistically significantly different (P = .33). Logistic regression analysis controlling for the covariates of age, race, and sex showed that patients with HIV in 2008 were 4.5 times more likely to present with verrucae compared to patients without HIV (95% confidence interval, 2.1-9.9, P = .0002).
patients with HIV infection in 2008 are still significantly more likely to present with plantar verrucae after controlling for age, race, and sex. This increased likelihood has not changed significantly across time. Because HAART has increased the life expectancy of patients with HIV, this group of patients with plantar verrucae will continue to represent a significant population in the practice of podiatric medicine.
自从高效抗逆转录病毒疗法（HAART）实施以来，人类免疫缺陷病毒（HIV）感染者的预期寿命显著增加。这可能会导致该人群足部医学表现的变化，比如跖疣。
2008年旧金山街头集市的参与者通过一项调查提供了有关HIV状况和疣存在情况的信息。总共分析了504份调查问卷，并与HAART实施前的1995年数据进行了比较。我们研究了1995年至2008年HIV阳性患者跖疣发生可能性增加是否有统计学上的显著变化。然后，我们通过逻辑回归分析，并控制年龄、性别和种族/民族因素，研究了2008年HIV阳性患者（与HIV阴性患者相比）出现跖疣的可能性。
2008年，HIV感染者出现跖疣的可能性是未感染HIV者的5.2倍（95%置信区间，2.5 - 11.0，P <.0001），1995年是10.0倍（95%置信区间，3.4 - 29.0，P <.0001）。随着时间推移这种可能性的降低在统计学上没有显著差异（P =.33）。对年龄、种族和性别协变量进行控制的逻辑回归分析表明，2008年HIV感染者出现疣的可能性是未感染HIV者的4.5倍（95%置信区间，2.1 - 9.9，P =.0002）。
在控制年龄、种族和性别因素后，2008年的HIV感染者出现跖疣的可能性仍然显著更高。这种增加的可能性随时间没有显著变化。由于HAART提高了HIV感染者的预期寿命，这组患有跖疣的患者将继续在足病医学实践中占相当大的比例。
