残余肾功能对新进入血液透析患者住院和死亡的影响。

The impact of residual renal function on hospitalization and mortality in incident hemodialysis patients.

机构信息

Department of Medicine, Nephrology Division, Beth Israel Medical Center, New York, NY 10003, USA.

出版信息

Blood Purif. 2011;31(4):243-51. doi: 10.1159/000322252. Epub 2011 Jan 14.

Abstract

BACKGROUND/AIMS: Few data are available on the impact of residual renal function (RRF) on mortality and hospitalization in hemodialysis (HD) patients. The objective of our study was to compare clinical outcomes for HD patients with and without RRF.

METHODS

In a cohort of 118 incident HD patients with RRF (n = 51) and without RRF (n = 67) who started dialysis in a single center, we recorded demographics, laboratory data, medication, hospitalizations and mortality.

RESULTS

Patients without RRF were older (p = 0.007), had lower baseline serum albumin levels (p = 0.002) and spent 18.6 more days in hospital per year than those with RRF (p = 0.055). Mean survival time was significantly lower in patients without RRF (p = 0.027). In a Cox proportional hazards model, only RRF remained as a significant independent predictor.

CONCLUSIONS

RRF is associated with significantly reduced mortality and hospital days, but does not decrease the hospitalization rate and time to first hospitalization.

摘要

背景/目的：关于残余肾功能 (RRF) 对血液透析 (HD) 患者死亡率和住院率的影响，数据有限。本研究的目的是比较有和无 RRF 的 HD 患者的临床结局。

方法

在单中心接受透析的 118 例有（n = 51）和无 RRF（n = 67）的新发 HD 患者队列中，我们记录了人口统计学、实验室数据、药物治疗、住院和死亡率。

结果

无 RRF 的患者年龄更大（p = 0.007），基线血清白蛋白水平更低（p = 0.002），每年住院天数比有 RRF 的患者多 18.6 天（p = 0.055）。无 RRF 的患者的平均生存时间明显更短（p = 0.027）。在 Cox 比例风险模型中，只有 RRF 仍然是显著的独立预测因素。