Takagi Shunsuke, Watanabe Yutaka, Imaoka Takefumi, Sakata Masuhiro, Watanabe Masako
Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan.
Clin Neuropharmacol. 2011 Jan-Feb;34(1):5-7. doi: 10.1097/WNF.0b013e318205070b.
Psychogenic polydipsia occurs frequently in patients with chronic psychiatric illness and is often unmanageable. We herein report 5 patients in whom acetazolamide was trialed for this symptom.
We encountered a case in which polydipsia improved with incidental administration of acetazolamide. We then used this treatment for 4 additional cases of treatment-resistant psychogenic polydipsia, some of which were accompanied by hyponatremia.
Acetazolamide improved polydipsia and/or hyponatremia in 4 of the 5 cases. This treatment was well tolerated and allowed 3 of the patients to permanently leave isolation.
Acetazolamide appears to have a beneficial effect in psychogenic polydipsia.
精神性烦渴在慢性精神疾病患者中频繁出现且往往难以控制。我们在此报告5例试用乙酰唑胺治疗该症状的患者。
我们遇到1例因偶然使用乙酰唑胺而烦渴症状改善的病例。然后我们将这种治疗方法用于另外4例难治性精神性烦渴患者，其中一些患者伴有低钠血症。
5例患者中有4例的烦渴和/或低钠血症得到改善。该治疗耐受性良好，使3例患者得以永久解除隔离。
乙酰唑胺似乎对精神性烦渴有有益作用。
