Hamilton Eye Institute, University of Tennessee Health Science Center, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Ophthalmic Plast Reconstr Surg. 2011 Jul-Aug;27(4):241-6. doi: 10.1097/IOP.0b013e318203d5e8.
To identify the type and frequency of ocular and orbital complications observed following treatment for primary rhabdomyosarcoma of the paranasal sinuses or the orbit.
An institutional review board-approved, Health Insurance Portability and Accountability Act-compliant retrospective chart review was conducted to identify all patients treated at one institution from 1966 to 2005 with biopsy-proven primary paranasal sinus or orbital rhabdomyosarcoma. Pretreatment, treatment, and follow-up data were collected.
Forty-four patients (25 male) of a median age of 7.8 years (range 1.0-18.0 years) with primary paranasal sinus (17) or orbital (27) rhabdomyosarcoma were treated and followed for a median period of 5.3 years (range 0.6-32.0 years). The three most frequently observed ophthalmic complications were persistent eyelid erythema or cellulitis (12), epithelial keratitis (7), and conjunctival injection (6) in the paranasal sinus and epithelial keratitis (18), conjunctival injection (11), and cataract (10) in the orbit. Overall survival after treatment trended higher for the orbital rhabdomyosarcoma group (23 of 27) than the paranasal sinus group (9 of 17).
The most frequently observed treatment-induced ophthalmic complications in the paranasal sinus group were manageable with minimal patient morbidity, as in the patients with orbital disease. Vision-threatening complications were infrequently encountered. Despite maximal therapy, the mortality rate was higher in the paranasal sinus rhabdomyosarcoma group than in the orbital rhabdomyosarcoma group.
确定经治疗后观察到的原发于鼻窦或眼眶横纹肌肉瘤的眼部和眼眶并发症的类型和频率。
进行了一项机构审查委员会批准的、符合《健康保险流通与责任法案》的回顾性图表审查，以确定 1966 年至 2005 年期间在一家机构接受治疗的所有经活检证实为原发鼻窦或眼眶横纹肌肉瘤的患者。收集了治疗前、治疗中和随访数据。
44 例（25 例男性）患者的中位年龄为 7.8 岁（范围 1.0-18.0 岁），患有原发鼻窦（17 例）或眼眶（27 例）横纹肌肉瘤，中位随访时间为 5.3 年（范围 0.6-32.0 年）。最常观察到的眼部并发症包括持续性眼睑红斑或蜂窝织炎（12 例）、上皮性角膜炎（7 例）和结膜充血（鼻窦 6 例），以及上皮性角膜炎（18 例）、结膜充血（11 例）和白内障（10 例）。治疗后，眼眶横纹肌肉瘤组（27 例中的 23 例）的总体生存率高于鼻窦组（17 例中的 9 例）。
鼻窦组最常观察到的治疗引起的眼部并发症是可管理的，患者的发病率较低，与眼眶疾病患者相似。危及视力的并发症很少发生。尽管采用了最大的治疗方法，但鼻窦横纹肌肉瘤组的死亡率高于眼眶横纹肌肉瘤组。
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