Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02142, USA.
Ophthalmic Plast Reconstr Surg. 2011 Jul-Aug;27(4):e87-8. doi: 10.1097/IOP.0b013e3181ef72a1.
Monoclonal antibody, ipilimumab, useful for treatment of metastatic melanoma, blocks CTLA-4 mediated T-cell suppression and can also cause a Graves ophthalmopathy like syndrome. Epidemiologic study has linked variant polymorphisms of CTLA-4 receptor gene to the presence of thyroid eye disease. The combination of these observations suggests CTLA-4 mediated T-cell functions are important to the pathogenesis of thyroid-associated eye disease.
单克隆抗体，易普利姆玛，可用于治疗转移性黑色素瘤，可阻断 CTLA-4 介导的 T 细胞抑制，也可引起格雷夫斯眼病样综合征。流行病学研究将 CTLA-4 受体基因的变异多态性与甲状腺眼病的存在联系起来。这些观察结果的结合表明 CTLA-4 介导的 T 细胞功能对甲状腺相关眼病的发病机制很重要。
