引言：寻找治愈 HIV 感染的挑战。
Introduction: challenges to finding a cure for HIV infection.
机构信息
VA San Diego Healthcare System, Department of Pathology, Center for AIDS Research, University of California, San Diego, California, USA.
出版信息
Curr Opin HIV AIDS. 2011 Jan;6(1):1-3. doi: 10.1097/COH.0b013e328340ffa6.
PURPOSE OF REVIEW
Renewed interest has emerged to address the latent reservoir of HIV to achieve a cure.
RECENT FINDINGS
The integrated proviral genome is a fundamental component of the retroviral replication cycle. The establishment of latently infected CD4+ lymphocytes, and perhaps other as yet poorly characterized cells, represents a reservoir of HIV infection that is not appreciably affected by effective antiretroviral chemotherapy. Effective management of HIV infection, thus, will require lifelong treatment unless an approach to purging this reservoir is identified. Although substantial insights about the latent reservoir have been made, our understanding about the details of the reservoirs, the mechanisms of latency and potential targets to eliminate latently infected cells is too primitive to achieve a cure without a great deal of basic research to elucidate some of these areas.
SUMMARY
A resurgence of interest in latent infection and its treatment promises progress in addressing the challenge of a cure, although, realistically, this will require a prolonged period of investigation in many areas.
目的综述
为实现治愈，人们重新产生了消除 HIV 潜伏库的兴趣。
最近的发现
整合前病毒基因组是逆转录病毒复制周期的基本组成部分。潜伏感染的 CD4+淋巴细胞的建立，以及可能其他尚未被充分描述的细胞，代表了 HIV 感染的一个储存库，它不会被有效的抗逆转录病毒化疗明显影响。因此，除非找到清除这种储存库的方法，否则 HIV 感染的有效管理将需要终身治疗。尽管对潜伏库有了大量的深入了解，但我们对储存库的细节、潜伏机制和潜在的消除潜伏感染细胞的靶点的理解还很原始，如果不进行大量的基础研究来阐明这些领域中的一些问题，就无法实现治愈。
总结
对潜伏感染及其治疗的重新关注有望在应对治愈挑战方面取得进展，尽管实际上，这将需要在许多领域进行长期的研究。
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