Center for Comparative Medicine, University of California, Davis, California, USA.
Curr Opin HIV AIDS. 2011 Jan;6(1):57-61. doi: 10.1097/COH.0b013e32834086ce.
This review will focus on recent developments in several nonhuman primate models of AIDS. These models are being used to address viral latency and persistence during antiretroviral therapy in studies that are not feasible in humans.
Further characterization of the various macaque models of AIDS has demonstrated that several aspects of viral persistence during antiretroviral therapy model HIV-1 infection in humans, including viral decay kinetics. Widespread distribution of viral RNA and viral DNA has been detected in many tissue organs. In addition, the brain has been identified as a site of persistent viral DNA.
The macaque models of AIDS are well suited for addressing viral persistence during antiretroviral therapy, including viral latency, residual replication, and tissue organ distribution.
本综述将重点介绍几种非人类灵长类动物艾滋病模型的最新进展。这些模型被用于解决在人类中不可行的抗逆转录病毒治疗期间的病毒潜伏和持续存在问题。
对各种猕猴艾滋病模型的进一步特征描述表明,在抗逆转录病毒治疗模型中,人类 HIV-1 感染的病毒持续存在的多个方面,包括病毒衰减动力学,与猕猴模型中的情况相似。已经在许多组织器官中检测到广泛分布的病毒 RNA 和病毒 DNA。此外,大脑已被确定为持续存在病毒 DNA 的部位。
艾滋病猕猴模型非常适合解决抗逆转录病毒治疗期间的病毒持续存在问题,包括病毒潜伏、残余复制和组织器官分布。