Bone Marrow and Stem Cell Transplantation Program, King Hussein Cancer Center (KHCC), Amman, Jordan.
Bone Marrow Transplant. 2011 Nov;46(11):1430-6. doi: 10.1038/bmt.2010.329. Epub 2011 Jan 17.
We retrospectively reviewed medical records of 39 hematopoietic SCT (HSCT) recipients who presented at our hospital between 1 October 2009 and 31 January 2010 with the 2009 H1N1 influenza infection. The median age at presentation was 13.8 years (range: 3.3-56.9), infections developed at a median of 585 days (range: 0-2316) post transplant, the majority (n=27, 69%) occurred in allogeneic HSCT recipients, 12 (31%) patients were on immunosuppressive therapy and 12 (31%) had GVHD. Lower airway disease was present in 8 patients (21%). In total, 15 patients (39%) were hospitalized with a median duration of 4.5 days (range: 3-27 days) and 3 (8%) required mechanical ventilation; 2 of whom died.
我们回顾性分析了 2009 年 10 月 1 日至 2010 年 1 月 31 日期间在我院就诊的 39 例造血干细胞移植(HSCT)受者的医学记录,这些患者均感染了 2009 年 H1N1 流感。就诊时的中位年龄为 13.8 岁(范围:3.3-56.9),感染发生于移植后中位时间 585 天(范围:0-2316),大多数(n=27,69%)发生于异基因 HSCT 受者,12 例(31%)患者正在接受免疫抑制治疗,12 例(31%)患者发生移植物抗宿主病。8 例(21%)患者存在下呼吸道疾病。共有 15 例(39%)患者住院,中位住院时间为 4.5 天(范围:3-27 天),3 例(8%)需要机械通气;其中 2 例死亡。