University of Heidelberg, Heidelberg, Germany.
Emerg Infect Dis. 2013 May;19(5):748-55. doi: 10.3201/eid1905.130034.
We studied risk factors for a severe clinical outcome in hospitalized patients with laboratory-confirmed influenza A(H1N1)pdm09 infection at the University Hospital Heidelberg in the pandemic and first postpandemic seasons. We identified 102 patients in 2009-10 and 76 in 2010-11. The proportion of severely diseased patients dramatically increased from 14% in 2009-10 to 46% in 2010-11 as did the mortality rate (5%-12%). Patients in the first postpandemic season were significantly older (38 vs. 18 years) and more frequently had underlying medical conditions (75% vs. 51%). Overall, 50 patients (28%) had a severe clinical outcome, resulting in 14 deaths. Multivariate analysis showed that older male patients with chronic lung disease were at increased risk for a severe clinical outcome. In summary, the proportion of patients with severe disease and fatal cases increased in the postpandemic season. Therefore, patients with suspected infections should be promptly identified and receive early treatment.
我们研究了在海德堡大学医院住院的甲型 H1N1pdm09 流感确诊患者中严重临床结局的危险因素，该研究在大流行和大流行后第一个季节进行。我们在 2009-10 年识别了 102 例患者，在 2010-11 年识别了 76 例。严重疾病患者的比例从 2009-10 年的 14%急剧增加到 2010-11 年的 46%，死亡率也从 5%增加到 12%。大流行后第一个季节的患者明显更年长（38 岁 vs. 18 岁），更常患有基础疾病（75% vs. 51%）。总体而言，50 名患者（28%）出现严重临床结局，导致 14 人死亡。多变量分析显示，患有慢性肺病的年长男性患者发生严重临床结局的风险增加。总之，大流行后季节中严重疾病和死亡病例的比例增加。因此，应及时识别疑似感染患者并给予早期治疗。
