人类基因表达的社会调控
Social regulation of human gene expression.
作者信息
Cole Steve W
机构信息
Department of Medicine, Division of Hematology-Oncology, UCLA School of Medicine, Cousins Center for PNI, UCLA AIDS Institute, Jonsson Comprehensive Cancer Center, the UCLA Molecular Biology Institute, and the HopeLab Foundation.
出版信息
Curr Dir Psychol Sci. 2009 Jun 1;18(3):132-137. doi: 10.1111/j.1467-8721.2009.01623.x.
Abstract
Relationships between genes and social behavior have historically been construed as a one-way street, with genes in control. Recent analyses have challenged this view by discovering broad alterations in the expression of human genes as a function of differing socio-environmental conditions. The emerging field of social genomics has begun to identity the types of genes subject to social regulation, the biological signaling pathways mediating those effects, and the genetic polymorphisms that moderate socio-environmental influences on human gene expression.
摘要
历史上，基因与社会行为之间的关系一直被看作是一条单行道，由基因掌控一切。最近的分析对这一观点提出了挑战，因为研究发现，人类基因的表达会随着社会环境条件的不同而发生广泛变化。新兴的社会基因组学领域已开始确定受社会调节的基因类型、介导这些效应的生物信号通路，以及调节社会环境对人类基因表达影响的基因多态性。
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