Thompson Judy L, Urban Nina, Abi-Dargham Anissa
Department of Psychiatry, Columbia University and New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.
Imaging Med. 2009 Dec 1;1(2):135-153. doi: 10.2217/IIM.09.22.
Molecular imaging techniques have led to significant advances in understanding the pathophysiology of schizophrenia and contributed to knowledge regarding potential mechanisms of action of the drugs used to treat this illness. The aim of this article is to provide a review of the major findings related to the application of molecular imaging techniques that have furthered schizophrenia research. This article focuses specifically on neuroreceptor imaging studies with PET and SPECT. After providing a brief overview of neuroreceptor imaging methodology, we consider relevant findings from studies of receptor availability, and dopamine synthesis and release. Results are discussed in the context of current hypotheses regarding neurochemical alterations in the illness. We then selectively review pharmacological occupancy studies and the role of neuroreceptor imaging in drug development for schizophrenia.
分子成像技术在理解精神分裂症的病理生理学方面取得了重大进展，并有助于了解用于治疗该疾病的药物的潜在作用机制。本文的目的是综述与分子成像技术应用相关的主要研究结果，这些结果推动了精神分裂症的研究。本文特别关注正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）的神经受体成像研究。在简要概述神经受体成像方法后，我们考虑了受体可用性、多巴胺合成和释放研究的相关结果。在当前关于该疾病神经化学改变的假说背景下对结果进行了讨论。然后，我们选择性地综述了药物占据研究以及神经受体成像在精神分裂症药物开发中的作用。
