Golmia Ricardo, Scheinberg Morton
Hospital Abreu Sodré-AACD and Hospital Israelita Albert Einstein, São Paulo, Brazil.
Rev Bras Reumatol. 2010 Nov-Dec;50(6):723-6.
The development of antinuclear antibodies after long-term use of anti-TNF therapy has been reported by several authors. The occurrence of lymphoproliferative neoplasms and, less commonly, solid tumors has also been reported. We present a case of simultaneous development of antinuclear antibodies and solid tumor in a patient with spondyloarthritis while on infliximab therapy. The implications and possible correlations with a solid tumor occurrence are reviewed and discussed.
几位作者报告了长期使用抗TNF治疗后抗核抗体的出现情况。也有关于淋巴增殖性肿瘤以及较少见的实体瘤发生的报道。我们报告了1例强直性脊柱炎患者在接受英夫利昔单抗治疗时同时出现抗核抗体和实体瘤的病例。对实体瘤发生的影响及可能的相关性进行了回顾和讨论。
