Johnson B J, Bruno J P
Department of Psychology, Ohio State University, Columbus 43210.
Neurosci Lett. 1990 Oct 2;118(1):120-3. doi: 10.1016/0304-3940(90)90263-9.
The effects of selective D1 and D2 antagonists on ingestive and locomotor behavior were studied in adult rats depleted of dopamine (DA) as neonates and their vehicle-treated controls. Blockade of either D1 or D2 receptors inhibited food intake and produced akinesia in control animals. Simultaneous administration of subthreshold doses of these antagonists produced similar behavioral deficits, indicating a synergism between the two receptor subtypes. In contrast, adults depleted of DA as neonates were unaffected by either D1 or D2 blockade. However, combined administration of these antagonists produced behavioral deficits comparable to those seen in controls. These data demonstrate that while activity within residual DA neurons remains critical for the expression of ingestive and locomotor behavior in rats depleted of DA as neonates, the precise nature of the interactions between the D1 and D2 receptor subtypes is altered after the depletion.
在新生期多巴胺（DA）耗竭的成年大鼠及其接受溶媒处理的对照大鼠中，研究了选择性D1和D2拮抗剂对摄食和运动行为的影响。阻断D1或D2受体均会抑制对照动物的食物摄入并导致运动不能。同时给予这些拮抗剂的阈下剂量会产生类似的行为缺陷，表明两种受体亚型之间存在协同作用。相比之下，新生期DA耗竭的成年大鼠对D1或D2阻断均无反应。然而，联合给予这些拮抗剂会产生与对照大鼠中所见相当的行为缺陷。这些数据表明，虽然残余DA神经元内的活性对于新生期DA耗竭的大鼠的摄食和运动行为的表达仍然至关重要，但在DA耗竭后，D1和D2受体亚型之间相互作用的确切性质发生了改变。
