Department of Medicine, Division of Neurology, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
Rheumatol Int. 2012 Apr;32(4):959-61. doi: 10.1007/s00296-010-1763-0. Epub 2011 Jan 18.
We report the case of a 66-year-old woman who developed progressive proximal muscle weakness and papillary thyroid cancer. After a thyroidectomy, she was treated with intravenous methylprednisolone pulse therapy and oral prednisolone followed by tacrolimus therapy. However, her clinical symptoms and laboratory data did not improve sufficiently. Therefore, we administered intravenous immunoglobulin. As a result, she regained substantial muscle strength along with complete normalization of serum muscle enzymes and showed no evidence of recurrence of papillary thyroid cancer or exacerbation of dermatomyositis (DM). Although there is controversy as to whether papillary thyroid cancer is involved in DM, the results of this study support a connection between these two conditions.
我们报告了一例 66 岁女性，她出现进行性近端肌肉无力和甲状腺乳头癌。甲状腺切除术后，她接受了静脉注射甲基强的松龙脉冲治疗和口服泼尼松龙，随后接受了他克莫司治疗。然而，她的临床症状和实验室数据没有得到充分改善。因此，我们给予了静脉注射免疫球蛋白。结果，她的肌肉力量显著恢复，血清肌肉酶完全正常，且没有甲状腺乳头癌复发或皮肌炎（DM）恶化的迹象。虽然甲状腺乳头癌是否与 DM 有关存在争议，但本研究的结果支持这两种情况之间存在关联。
