[夜间阴茎勃起及他达拉非对勃起功能障碍的影响]
[Nocturnal penile tumescence and the effect of tadalafil on erectile dysfunction].
作者信息
Xiao Fei, Yan Zhi-An, Gu Xian-En, Bai Wen-Jun, Wang Xiao-Feng
机构信息
Department of Urology, Beijing Chuiyangliu Hospital, Beijing 100022, China.
出版信息
Zhonghua Nan Ke Xue. 2010 Oct;16(10):954-8.
OBJECTIVE
To explore the correlation between the results of the nocturnal penile tumescence (NPT) test and the efficacy of tadalafil in the treatment of ED.
METHODS
A total of 188 ED patients were divided into a normal NPT group (n = 136) and an abnormal NPT group (n = 52) according to the results of the NPT test. All of them were treated with tadalafil at 20 mg 3 times a week. The IIEF-5 score, SEP2, SEP3 and GAQ score were compared between the two groups before and 1 month after the treatment.
RESULTS
Tadalafil treatment significantly improved IIEF-5 score, SEP2 and SEP3 of both groups of the patients (P < 0.01). Compared with the abnormal NPT group, the normal NPT group showed a remarkable increase in the IIEF-5 score, SEP2, SEP3 (P < 0.05) and GAQ score (P < 0.01).
CONCLUSION
After 1 month of tadalafil treatment, the normal NPT group achieved a more significant improvement of erectile function and sexual satisfaction than the abnormal NPT group, suggesting that tadalafil has a better therapeutic effect for ED patients with normal NPT.
目的
探讨夜间阴茎勃起（NPT）试验结果与他达拉非治疗勃起功能障碍（ED）疗效之间的相关性。
方法
根据NPT试验结果，将188例ED患者分为NPT正常组（n = 136）和NPT异常组（n = 52）。所有患者均接受他达拉非治疗，每周3次，每次20 mg。比较两组患者治疗前及治疗1个月后的国际勃起功能指数-5（IIEF-5）评分、SEP2、SEP3和GAQ评分。
结果
他达拉非治疗显著改善了两组患者的IIEF-5评分、SEP2和SEP3（P < 0.01）。与NPT异常组相比，NPT正常组的IIEF-5评分、SEP2、SEP3（P < 0.05）和GAQ评分（P < 0.01）显著升高。
结论
他达拉非治疗1个月后，NPT正常组勃起功能和性满意度的改善比NPT异常组更显著，提示他达拉非对NPT正常的ED患者具有更好的治疗效果。
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