Marin Ludmila Violeta, Ferariu D, Mihailovici Maria-Sultana
Doctorand al Universităţii de Medicină şi Farmacie Gr.T. Popa Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2010 Jul-Sep;114(3):818-22.
The morphologic information from usual hematoxiline-eosine staining are sometimes insufficient in certifying or excluding the adenocarcinoma of the prostate, cases who must be study by immunohistochemistry.
The investigation of staining for CK5/6 and P63 in cases diagnosed with prostate adenocarcinoma associated with high grade prostatic intraepithelial neoplasia.
The study was realized on 56 cases analyzed in Pathology Laboratory of Focşani Emergency Hospital.
We registered a positive correct diagnosis for atypical adenomatous hyperplasia in 86% of cases and for prostate adenocarcinoma grade 1 in 14% of cases.
CK5/6 and P63 are useful markers for elucidating a positive false diagnosis for prostate adenocarcinoma grade 1.
常规苏木精-伊红染色的形态学信息有时不足以确诊或排除前列腺腺癌，此类病例必须通过免疫组织化学进行研究。
研究细胞角蛋白5/6（CK5/6）和P63在诊断为前列腺腺癌伴高级别前列腺上皮内瘤变的病例中的染色情况。
该研究在福克沙尼急救医院病理实验室分析的56例病例中进行。
我们记录到，86%的病例对非典型腺瘤样增生诊断正确且呈阳性，14%的病例对1级前列腺腺癌诊断正确且呈阳性。
CK5/6和P63是有助于阐明1级前列腺腺癌假阳性诊断的有用标志物。
