通过 o-炔基芳基异氰化物与碘的光化学环化合成 2,4-二碘喹啉。
Synthesis of 2,4-diiodoquinolines via the photochemical cyclization of o-alkynylaryl isocyanides with iodine.
机构信息
Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
出版信息
J Org Chem. 2011 Feb 18;76(4):1163-6. doi: 10.1021/jo1021772. Epub 2011 Jan 18.
PMID:21244063
Abstract
Upon photoirradiation of o-alkynylaryl isocyanides in the presence of iodine, the intramolecular cyclization of o-alkynylaryl isocyanides proceeds to afford the corresponding 2,4-diiodoquinolines in good yields. 2,4-Diiodoquinolines can be employed in transition metal-catalyzed cross-coupling reactions.
摘要
在碘存在下光照射邻炔基芳基异氰化物时，邻炔基芳基异氰化物发生分子内环化反应，以良好的收率得到相应的 2,4-二碘喹啉。2,4-二碘喹啉可用于过渡金属催化的交叉偶联反应。
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