Department of Pharmaceutics, China Pharmaceutical University, Nanjing, P. R. China.
Drug Dev Ind Pharm. 2011 Aug;37(8):894-900. doi: 10.3109/03639045.2010.548067. Epub 2011 Jan 19.
The aim of this study was to characterize the microstructure of microemulsion consisting of oleic acid, Cremophor RH40, ethanol, and water (K(m) = 2), and investigate the influence of microstructure on the solubilization potential of the microemulsion to meloxicam (MLX).
Pseudo-ternary phase diagrams of microemulsion were constructed using the H2O titration method. The microstructures of microemulsion on dilution line N91 were identified by means of conductivity, viscosity, surface tension, and density. The freeze-fracture electron microscopy proved the specific microstructure. Differential scanning calorimetry (DSC) was used to evaluate the position of MLX in microemulsion, and the solubility of MLX in chosen microemulsions on dilution line N91 was measured.
The three microstructures along dilution line N91, including water-in-oil (W/O), bicontinuous (BC), and oil-in-water (O/W) microemulsion, were characterized. The solubilization capacity of W/O microemulsion is the best, compared with the other two, whereas the O/W is the weakest. A possible structure model has been applied for the explanation of difference.
The solubilization capacity of microemulsion is closely related with its microstructure.
本研究旨在描述由油酸、吐温 RH40、乙醇和水（K(m) = 2）组成的微乳液的微观结构，并研究微观结构对微乳液溶解美洛昔康（MLX）能力的影响。
采用 H2O 滴定法构建微乳液的伪三元相图。通过电导率、粘度、表面张力和密度的方法，对稀释线 N91 上的微乳液的微观结构进行鉴定。冷冻断裂电子显微镜证明了特定的微观结构。差示扫描量热法（DSC）用于评估 MLX 在微乳液中的位置，并测量稀释线 N91 上选定微乳液中 MLX 的溶解度。
沿线 N91 上的三种微观结构，包括油包水（W/O）、双连续（BC）和水包油（O/W）微乳液，都具有特征。与其他两种相比，W/O 微乳液的溶解能力最好，而 O/W 则最差。已经提出了一种可能的结构模型来解释这种差异。
微乳液的溶解能力与其微观结构密切相关。
