在维生素D摄入量受控的情况下，二苯妥英对雏鸡骨骼变化的影响。

Bone changes induced by diphenylhydantoin in chicks on a controlled vitamin D intake.

作者信息

Villareale M E, Chiroff R T, Bergstrom W H, Gould L V, Wasserman R H, Romano F A

出版信息

J Bone Joint Surg Am. 1978 Oct;60(7):911-6.

Abstract

Florid rickets developed in chicks receiving doses of diphenylhydantoin analogous to doses used in humans as anticonvulsants, vitamin D3 being given in amounts sufficient for normal bone mineralization in controls. The changes in the bones were directly related to the dose of diphenylhydantoin and inversely related to the dose of vitamin D3. Bone mineralization was assessed by roentgenography, histological examination, microradiography, and measurement of bone ash. Of these methods, roentgenography was the least sensitive. Rachitic changes were detectable by light microscopy and microradiography in chicks whose skeletons appeared normal roentgenographically. Roentgenographic evidence of rickets became detectable only when the rickets was far advanced. Rickets developed at serum levels of diphenylhydantoin similar to those found in patients taking anticonvulsant medication.

摘要

接受与人类抗惊厥药物剂量相当的苯妥英剂量的雏鸡出现了典型的佝偻病，同时给予对照组足以实现正常骨矿化的维生素D3量。骨骼的变化与苯妥英剂量直接相关，与维生素D3剂量呈负相关。通过X线摄影、组织学检查、显微放射摄影和骨灰测量来评估骨矿化。在这些方法中，X线摄影最不敏感。骨骼X线表现正常的雏鸡，通过光学显微镜和显微放射摄影可检测到佝偻病变化。只有当佝偻病非常严重时，X线摄影才能检测到佝偻病的证据。在与服用抗惊厥药物患者相似的苯妥英血清水平下，雏鸡出现了佝偻病。