Roentgenographic changes during long-term diphenylhydantoin therapy.

Diphenylhydantoin (Dilantin) is a well known anticonvulsant with well documented effectiveness. The complications, unfortunately, are multiple and well recognized clinically. This paper deals with the roentgenographic changes encountered in long-term diphenylhydantoin use. Some of these changes, which are not clinically readily apparent, may alert unwary physicians in the recognition of diphenylhydantoin-induced disease.