Cunningham Teresa E, Sayers Susan M, Singh Gurmeet R
Menzies School of Health Research, Casuarina, Northern Territory, Australia.
J Paediatr Child Health. 2011 May;47(5):257-61. doi: 10.1111/j.1440-1754.2010.01955.x. Epub 2011 Jan 18.
To describe the lipoprotein(a) (Lp(a))profile and its relationship to cardiovascular risk factors in Australian Aboriginal children.
A cross-sectional study within a longitudinal birth cohort study in the Darwin Health Region (Northern Territory, Australia). Subjects were Aboriginal children born between 1987 and 1990 who were re-examined between 1998 and 2001. Outcome measures were cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apoB, apoA1, apoA1/B ratio, anthropometric measures, cardiovascular disease (CVD) risk factors, maternal smoking and nutrition.
At a mean age of 11.4 years, results showed that high concentrations of Lp(a) were significantly related to well-known lipid-based CVD risk factors for both boys and girls, and that only one anthropometric factor, height, was significant for girls. Non-genetic factors and maternal smoking were not found to be significant contributors to Lp(a) concentrations.
Lp(a) should be considered as a more effective marker of CVD than anthropometric measures, and children from families with a history of premature CVD should be regularly screened for this factor.
描述澳大利亚原住民儿童的脂蛋白(a)（Lp(a)）特征及其与心血管危险因素的关系。
在澳大利亚北领地达尔文健康区进行的一项纵向出生队列研究中的横断面研究。研究对象为1987年至1990年出生、于1998年至2001年接受复查的原住民儿童。观察指标包括胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白B、载脂蛋白A1、载脂蛋白A1/载脂蛋白B比值、人体测量指标、心血管疾病（CVD）危险因素、母亲吸烟情况和营养状况。
在平均年龄11.4岁时，结果显示，高浓度的Lp(a)与男孩和女孩基于脂质的知名CVD危险因素显著相关，且对于女孩而言，只有一个人体测量因素（身高）具有显著性。未发现非遗传因素和母亲吸烟是Lp(a)浓度升高的显著影响因素。
与人体测量指标相比，Lp(a)应被视为更有效的CVD标志物，有过早发生CVD家族史的儿童应定期筛查该因素。
