Departments of Medicine, Pharmacology, and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-6602, USA.
Trends Cardiovasc Med. 1994 Nov-Dec;4(6):278-85. doi: 10.1016/1050-1738(94)90032-9.
Clinical evidence strongly suggests that the electrophysiologic behavior of the heart, and its response to drugs, is a highly dynamic process. Ion channels are the fundamental molecular units determining cardiac excitability. The cloning of ion channels that are responsible for the generation and maintenance of the cardiac action potential will enable studies of the molecular mechanisms underlying the highly heterogeneous nature of cardiac electrophysiology. The molecular bases of important pathophysiologic events, such as acute regulation of channel function by phosphorylation or drug block, or the long-term electrophysiologic changes accompanying diseases such as hypertension, are now being elucidated. Identification of these molecular mechanisms may point to novel approaches to the treatment of cardiac arrhythmias.
临床证据强烈表明，心脏的电生理行为及其对药物的反应是一个高度动态的过程。离子通道是决定心脏兴奋性的基本分子单位。负责产生和维持心脏动作电位的离子通道的克隆，将使人们能够研究心脏电生理学高度异质性的分子机制。目前，正在阐明重要病理生理事件的分子基础，如通过磷酸化或药物阻断对通道功能的急性调节，或高血压等疾病伴随的长期电生理变化。这些分子机制的鉴定可能为心律失常的治疗提供新的方法。
