免疫调节疗法在系统性硬化症中的作用
Effects of immunomodulating therapy in systemic sclerosis.
作者信息
van den Hoogen F H, Boerbooms A M, van de Putte L B
机构信息
Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
出版信息
Clin Rheumatol. 1990 Sep;9(3):319-24. doi: 10.1007/BF02114391.
PMID:2124530
Abstract
We reviewed studies concerning immunomodulating therapy in systemic sclerosis. These comprise mostly uncontrolled trials and case reports. Some of these studies hint at a possible beneficial effect of antimetabolites (azathioprine, 5-fluoro-uracil and methotrexate), cyclosporine and interferon-gamma. However, to give a clearcut answer on the efficacy of these drugs in systemic sclerosis, controlled studies are urgently needed.
摘要
我们回顾了关于系统性硬化症免疫调节治疗的研究。这些研究大多为非对照试验和病例报告。其中一些研究暗示抗代谢药物（硫唑嘌呤、5-氟尿嘧啶和甲氨蝶呤）、环孢素和干扰素-γ可能具有有益效果。然而，要明确这些药物在系统性硬化症中的疗效，迫切需要进行对照研究。
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本文引用的文献
1
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Am J Med. 1964 Aug;37:195-205. doi: 10.1016/0002-9343(64)90005-1.
2
Association of antinuclear and antinucleolar antibodies in progressive systemic sclerosis.进行性系统性硬化症中抗核抗体与抗核仁抗体的关联。
Clin Exp Immunol. 1982 Apr;48(1):43-51.
3
Plasmapheresis and immunosuppressive drug therapy in scleroderma.
Arthritis Rheum. 1981 Sep;24(9):1128-36. doi: 10.1002/art.1780240903.
4
Lymphocytes in the skin of patients with progressive systemic sclerosis. Quantification, subtyping, and clinical correlations.进行性系统性硬化症患者皮肤中的淋巴细胞。定量、亚型分析及临床相关性
Arthritis Rheum. 1984 Jun;27(6):645-53. doi: 10.1002/art.1780270607.
5
Diversity of antinuclear antibodies in progressive systemic sclerosis. Anti-centromere antibody and its relationship to CREST syndrome.进行性系统性硬化症中抗核抗体的多样性。抗着丝点抗体及其与CREST综合征的关系。
Arthritis Rheum. 1980 Jun;23(6):617-25. doi: 10.1002/art.1780230602.
6
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Rev Rhum Mal Osteoartic. 1968 Dec;35(12):649-56.
7
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Arch Dermatol. 1968 Jun;97(6):690-8. doi: 10.1001/archderm.97.6.690.
8
[So-called immunosuppressive cytotoxic medication in acute disseminated lupus erythematosus and scleroderma].
Bull Soc Fr Dermatol Syphiligr. 1970;77(3):412-4.
9
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10
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Arthritis Rheum. 1974 Jul-Aug;17(4):375-82. doi: 10.1002/art.1780170406.
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