组蛋白 H3K4 甲基化使着丝粒保持开放状态。
Histone H3K4 methylation keeps centromeres open for business.
机构信息
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
出版信息
EMBO J. 2011 Jan 19;30(2):233-4. doi: 10.1038/emboj.2010.339.
Abstract
Nucleosomes at eukaryotic centromeres combine the histone H3 variant CENP-A and canonical H3 di-methylated at lysine 4 (H3K4me2), whose functional importance within the centromere region remains elusive. In this issue, Bergmann reveal a role for H3K4me2 in CENP-A maintenance, and extend the profile of centromeric histone modifications to include H3K36 methylation, typically found in transcribed regions of the genome.
摘要
真核着丝粒处的核小体结合组蛋白 H3 变体 CENP-A 和赖氨酸 4 二甲基化的典型 H3（H3K4me2），但其在着丝粒区域的功能仍不清楚。在本期杂志中，Bergmann 揭示了 H3K4me2 在 CENP-A 维持中的作用，并将着丝粒组蛋白修饰的特征扩展到包括基因组转录区域中通常发现的 H3K36 甲基化。
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