Bonitenko E Y, Grebenyuk A N, Basharin V A, Ivanov M B, Makarova N V
Institute of Toxicology, Federal Biomedical Agency of Russia, St. Petersburg, Russia.
Bull Exp Biol Med. 2010 Sep;149(3):324-7. doi: 10.1007/s10517-010-0938-8.
Approaches to evaluation of the severity of neurological disorders in animals with experimental acute severe alcohol intoxication were developed. Using the method of statistical analysis, we selected criteria, which can be used for evaluation of the severity of inhibition of the nervous system in studies of the alcoholism pathogenesis and for improvement of methods for correction of severe intoxication at the preclinical stage of drug efficiency evaluation.
已开发出评估实验性急性重度酒精中毒动物神经障碍严重程度的方法。通过统计分析方法，我们选择了一些标准，这些标准可用于在酒精中毒发病机制研究中评估神经系统抑制的严重程度，并用于在药物疗效评估的临床前阶段改进重度中毒的纠正方法。
