Laboratoire de Chimie Physique (former EA4066), Faculté de Pharmacie, Université Paris Descartes, 75006 Paris, France.
J Pharm Sci. 2011 Jun;100(6):2258-66. doi: 10.1002/jps.22460. Epub 2011 Jan 18.
The solid-state properties of antiprotozoal ternidazole (3-(2-methyl-5-nitroimidazol-1-yl)-propan-1-ol) have been studied. Crystals are triclinic in the temperature interval between 100 and 333 K (melting point) with two different molecular conformations present in the asymmetric unit (Z' = 2) and two of each conformer make up a tetramer held together by hydrogen bonding. Its melting enthalpy at 333 K is 25.65 (± 1.29) kJ · mol(-1). Linear plots were obtained for the melting temperature versus pressure (dP/dT = 5.67 (± 0.08) MPa · K(-1)] and the glass transition versus pressure [dP/dT = 7.73 (±1.76) MPa · K(-1)]. No crystalline polymorphism could be detected; thus, the single-crystal structure that has been found is most likely the stable one.
抗原生动物药物替硝唑（3-(2-甲基-5-硝基咪唑-1-基）-1-丙醇）的固态性质已经过研究。在 100 至 333 K（熔点）之间的温度范围内，晶体为三斜晶系，在不对称单元（Z' = 2）中存在两种不同的分子构象，每个构象各有两种，通过氢键形成四聚体。在 333 K 时的熔融焓为 25.65（±1.29）kJ·mol（-1）。熔融温度与压力的线性关系为（dP/dT = 5.67（±0.08）MPa·K（-1）]和玻璃化转变与压力的线性关系为 [dP/dT = 7.73（±1.76）MPa·K（-1）]。未检测到结晶多态性；因此，所发现的单晶结构很可能是稳定的。
