Program of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Head Neck. 2011 Oct;33(10):1426-32. doi: 10.1002/hed.21616. Epub 2011 Jan 18.
A subset of thyroid tumors characterized by a follicular growth pattern can represent a serious diagnosis. Immunohistochemistry and molecular pathology for genetic profiling have been used in an attempt to resolve some of these issues.
Tumor tissue samples of thyroid were obtained from 70 patients who underwent surgical therapy. They were divided into 4 groups: 20 adenomatous goiters, 10 follicular adenomas, 24 papillary carcinomas, and 16 follicular carcinomas. Immunohistochemical analysis was carried out using antibodies for MAGE-A4 (melanoma antigen-encoding gene A4) and MAGE-C1 (melanoma antigen-encoding gene C1).
Standard histologic analysis and immunohistochemistry analysis of MAGE-A4 and MAGE-C1 expression were performed in all patients. The antigens examined were not expressed in any of the tissues.
The malignant degeneration of normal tissues is a multifactorial process, varying considerably both among tumor types and among individual patients. The present study showed that there was no immunolabeling of the MAGE-A4 and MAGE-C1 antigens.
具有滤泡生长模式的甲状腺肿瘤亚组可能代表严重的诊断。为了解决其中的一些问题，已经使用免疫组织化学和分子病理学进行基因分析。
从 70 名接受手术治疗的甲状腺肿瘤患者中获得肿瘤组织样本。将它们分为 4 组：20 例腺瘤性甲状腺肿、10 例滤泡性腺瘤、24 例乳头状癌和 16 例滤泡癌。使用针对 MAGE-A4（黑素瘤抗原编码基因 A4）和 MAGE-C1（黑素瘤抗原编码基因 C1）的抗体进行免疫组织化学分析。
对所有患者进行了标准组织学分析和 MAGE-A4 和 MAGE-C1 表达的免疫组织化学分析。所检查的抗原在任何组织中均未表达。
正常组织的恶性转化是一个多因素的过程，在肿瘤类型和个体患者之间变化很大。本研究表明，MAGE-A4 和 MAGE-C1 抗原没有免疫标记。
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