Pasini Evasio, Pirelli Salvatore, Di Lenarda Andrea, Dioguardi Francesco S, Maseri Attilio
Fondazione S. Maugeri, IRCCS Centro Medico di Lumezzane, Lumezzane (BS), Italy.
G Ital Cardiol (Rome). 2010 Oct;11(10):761-6.
Medical research and consequently therapy are undergoing dramatic transformation. New science on genomics and proteomics has given us important information on the pathophysiology of many cardiac diseases and personalized responses to specific patient-oriented therapies. The application of cellular genetic and proteome tests is a promising field of research and their clinical use can allow us to both: 1) understand the causes and evolution of heart diseases such as ischemia and heart failure better, 2) lead to personalized medicine. This article focuses on the basic intracellular-related evidence and the unsolved problems and complexity of intracellular signaling that still need to be studied to understand personalized therapies better. In addition, we provide preliminary clinical data that support the potentiality of this new but fundamental approach of curing patients according to their genetic expression and/or protein activation that influence personalized development and the management of cardiovascular diseases.
医学研究以及随之而来的治疗正在经历巨大变革。基因组学和蛋白质组学的新科学为我们提供了许多心脏疾病病理生理学以及针对特定患者的疗法的个性化反应的重要信息。细胞遗传学和蛋白质组测试的应用是一个很有前景的研究领域，其临床应用能使我们：1）更好地理解诸如缺血和心力衰竭等心脏病的病因及演变，2）实现个性化医疗。本文聚焦于与细胞内相关的基础证据以及细胞内信号传导中仍有待研究以更好理解个性化疗法的未解决问题和复杂性。此外，我们提供了初步临床数据，这些数据支持了这种根据影响个性化发展和心血管疾病管理的基因表达和/或蛋白质激活来治疗患者的新的基础方法的潜力。
