Chana F R, Guisáosla M Z, Sánchez J H, Villanueva M M, Calvo J H, Vaquero J M
Hospital General Universitario Gregorio Marañón.
Acta Ortop Mex. 2010 Sep-Oct;24(5):298-305.
Thanks to defense mechanisms, organisms have had to adapt themselves to an adverse natural setting that causes acute and chronic stress. This adaptive response that tries to protect the cells against lethal insults uses its own defense systems.
Prospective, observational, descriptive pilot study with analytic components to determine the baseline preoperative TNF levels of 35 patients undergoing total knee arthroplasty due to gonarthrosis. Ten patients with a diagnosis of infected total knee arthroplasty were also included. In order to find differences and possible associations, the Mann-Whitney U test or the Fisher test was used to compare the variables between the non-infected group of patients and the group with the infection complication.
We found a statistically significant difference; higher levels of fibrinogen, erythrocyte sedimentation rate, C-reactive protein, TNF-alpha and temperature were found in the infected patients; temperature was not clinically relevant.
In the absence of a diagnostic specificity, the combined determinations of acute phase reactants may be useful to detect the presence and intensity of the inflammatory and infectious processes.
由于防御机制，生物体不得不使自身适应导致急性和慢性应激的不利自然环境。这种试图保护细胞免受致命损伤的适应性反应会动用自身的防御系统。
一项具有分析成分的前瞻性、观察性、描述性试点研究，以确定35例因膝关节病接受全膝关节置换术患者的术前肿瘤坏死因子（TNF）基线水平。还纳入了10例诊断为感染性全膝关节置换术的患者。为了找出差异和可能的关联，采用曼-惠特尼U检验或费舍尔检验来比较非感染患者组和有感染并发症患者组之间的变量。
我们发现了统计学上的显著差异；感染患者的纤维蛋白原、红细胞沉降率、C反应蛋白、肿瘤坏死因子-α和体温水平更高；体温在临床上并无关联。
在缺乏诊断特异性的情况下，联合测定急性期反应物可能有助于检测炎症和感染过程的存在及强度。
