花生四烯酸的细胞色素P - 450代谢产物：对血压调节的影响

Cytochrome P-450 metabolites of arachidonic acid: implications for blood pressure regulation.

作者信息

Carroll M A, Escalante B, McGiff J C

机构信息

Department of Pharmacology, New York Medical College, Valhalla 10595.

出版信息

Pol J Pharmacol Pharm. 1990 May-Jun;42(3):191-201.

PMID:2124686

Abstract

In the presence of NADPH cytochrome P-450-dependent monooxygenases oxidize arachidonic acid giving rise to four epoxyeicosatrienoic acids (EETs) which are hydrolyzed enzymatically to dihydroxyeicosatrienoic acids (DHETs). EETs generate vasodilators. Allylic oxidation forms hydroxyeicosatetraenoic acids, of which 12(R)HETE is an inhibitor of Na(+)-K(+)-ATPase and renin release. Finally, omega and omega-1 hydroxylation of arachidonic acid generates 20- and 19-HETEs which are involved in the development of hypertension in SHR rats.

摘要

在烟酰胺腺嘌呤二核苷酸磷酸（NADPH）细胞色素P-450依赖性单加氧酶的作用下，花生四烯酸被氧化生成四种环氧二十碳三烯酸（EETs），这些EETs会被酶水解为二羟基二十碳三烯酸（DHETs）。EETs可生成血管舒张剂。烯丙基氧化形成羟基二十碳四烯酸，其中12（R）-HETE是钠钾ATP酶和肾素释放的抑制剂。最后，花生四烯酸的ω和ω-1羟基化生成20-和19-HETEs，它们参与自发性高血压大鼠（SHR）高血压的发展。