Egyptian International fertility & IVF Center, Miser International Hospital, Cairo, Egypt.
Gynecol Endocrinol. 2011 Oct;27(10):789-93. doi: 10.3109/09513590.2010.540600. Epub 2011 Jan 19.
Women with polycystic ovary syndrome (PCOS) are at a high risk to develop Gestational Diabetes mellitus (GDM). We hypothesized that metformin due to its metabolic, endocrine, vascular, and anti-inflammatory effects may reduce the incidence of GDM in PCOS women.
We carried out a prospective cohort study to determine the beneficial effects of metformin on PCOS patients during pregnancy. Three-hundred and sixty non-diabetic PCOS patients were included who were conceived on metformin by different treatment modalities. Two-hundred pregnant women continued on metformin at a dose of 1000-2000 mg daily throughout pregnancy (study group) and 160 women discontinued metformin use at the time of conception (control group).
There is a statistically significant reduction in the incidence of GDM in favor of metformin group (OR: 0.17, 95% CI: 0.07-0.37). There is a statistically significant reduction in the incidence of pre-eclampsia in favor of metformin group (OR: 0.35, 95% CI: 0.13-0.94).
Metformin is a promising medication for the prevention or reduction of the incidence of GDM and pre-eclampsia in PCOS women.
多囊卵巢综合征（PCOS）女性发生妊娠糖尿病（GDM）的风险较高。我们假设二甲双胍由于其代谢、内分泌、血管和抗炎作用，可能会降低 PCOS 女性 GDM 的发生率。
我们进行了一项前瞻性队列研究，以确定二甲双胍对妊娠期间 PCOS 患者的有益作用。共纳入 360 名非糖尿病 PCOS 患者，她们通过不同的治疗方式接受了二甲双胍治疗而受孕。200 名孕妇在整个孕期继续使用二甲双胍（剂量为 1000-2000mg/天）（研究组），而 160 名孕妇在受孕时停止使用二甲双胍（对照组）。
二甲双胍组 GDM 的发生率明显降低（OR：0.17，95%CI：0.07-0.37）。二甲双胍组子痫前期的发生率明显降低（OR：0.35，95%CI：0.13-0.94）。
二甲双胍是预防或降低 PCOS 女性 GDM 和子痫前期发生率的有前途的药物。
