Department of Cardiology, University of Alabama at Birmingham, Birmingham, AL.
Am J Ther. 2013 Sep-Oct;20(5):569-71. doi: 10.1097/MJT.0b013e3182053ee1.
Almost 50 years after its discovery, valproic acid remains a mainstay in the treatment of epilepsy, both alone and in combination with other anticonvulsants. It is also associated with a hyperammonemic encephalopathy, when used in combination with other drugs. We present a case of valproate-induced hyperammonemic encephalopathy in a patient on multiple anticonvulsant and psychotropic medications. The patient presented with altered mental status and became progressively more obtunded and finally began to experience seizures. Her symptoms resolved with the discontinuation of valproic acid and with supportive care.
近 50 年来，丙戊酸一直是治疗癫痫的主要药物，无论是单独使用还是与其他抗惊厥药物联合使用。当与其他药物联合使用时，它也与高氨血症性脑病有关。我们报告了一例多药抗惊厥和精神药物治疗的患者发生丙戊酸诱导的高氨血症性脑病。该患者表现为精神状态改变，并逐渐变得更加迟钝，最终开始出现癫痫发作。她的症状随着丙戊酸的停用和支持性治疗而缓解。
