丙戊酸盐诱发的以紧张症为表现的高氨血症性脑病

Valproate-induced Hyperammonemic Encephalopathy Presenting as Catatonia.

作者信息

Pérez-Esparza Rodrigo, Oñate-Cadena Nelcy, Ramírez-Bermúdez Jesús, Espínola-Nadurille Mariana

机构信息

Department of Neuropsychiatry, National Institute of Neurology and Neurosurgery.

Addiction Research Laboratory, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.

出版信息

Neurologist. 2018 Mar;23(2):51-52. doi: 10.1097/NRL.0000000000000166.

DOI:10.1097/NRL.0000000000000166

PMID:29494435

Abstract

Hyperammonemic encephalopathy secondary to the use of valproate is rare without evidence of hepatotoxicity, and it usually presents with confusion, agitation, irritability, cognitive disturbances, lethargy, coma, and death. We present the case of a 21-year-old woman presenting with catatonia as a manifestation of hyperammonemic encephalopathy that resolved with the normalization of ammonia and suspension of valproate.

摘要

在没有肝毒性证据的情况下，使用丙戊酸盐继发的高氨血症性脑病很罕见，其通常表现为意识模糊、躁动、易怒、认知障碍、嗜睡、昏迷及死亡。我们报告一例21岁女性病例，该患者以紧张症为高氨血症性脑病的一种表现形式，随着氨水平恢复正常及停用丙戊酸盐，症状得以缓解。