Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Curr Opin Gastroenterol. 2011 May;27(3):262-7. doi: 10.1097/MOG.0b013e3283438a26.
Benign biliary diseases are often managed endoscopically using plastic stents. Benign biliary strictures (BBS) respond to placement of multiple large-bore plastic stents, though requiring multiple procedures to place stents, and to exchange stents to prevent and/or treat stent occlusion. Bile leaks close using plastic stents, which divert bile away from the leak into the duodenum. Covered self-expandable metal stents (CSEMS), intended for palliation of malignant biliary obstruction, have been used to treat benign biliary diseases. Advantages include small predeployment and large postexpansion diameters. Lack of imbedding of the metal into the bile duct wall enables removability.
For strictures, one CSEMS is inserted without need for dilation and remains in place for up to 6 months. Successful removal has been reported in all cases. Long-term stricture resolution is achieved in up to 92%. Adverse events include migration and new stricture formation. For treatment of complex bile leaks, the covering and large diameter allow successful closure in nearly all cases. Other uses of CSEMS include treatment of postsphincterotomy bleeding and closure of perforations.
CSEMS show promise for treatment of BBS and complex biliary leaks. Successful resolution can be achieved in the majority of patients with the advantage of fewer procedures, which offsets their higher cost.
良性胆道疾病常采用塑料支架进行内镜治疗。良性胆道狭窄(BBS)可通过放置多个大口径塑料支架来缓解,尽管需要多次手术放置支架,并更换支架以预防和/或治疗支架阻塞。塑料支架可使胆汁漏关闭,将胆汁从漏口引流至十二指肠。旨在缓解恶性胆道梗阻的覆膜自膨式金属支架(CSEMS)已用于治疗良性胆道疾病。其优点包括支架预扩张和后扩张直径小。金属未嵌入胆管壁,可进行移除。
对于狭窄,无需扩张即可插入一个 CSEMS,最长可放置 6 个月。所有病例均成功取出。高达 92%的患者实现了长期狭窄缓解。不良事件包括迁移和新狭窄形成。对于复杂胆汁漏的治疗,覆盖物和大直径可使几乎所有病例成功闭合。CSEMS 的其他用途包括治疗括约肌切开术后出血和穿孔闭合。
CSEMS 有望治疗 BBS 和复杂胆汁漏。大多数患者可获得成功缓解,且由于手术次数减少,其成本优势抵消了费用较高的劣势。