Divisione di Medicina, Ospedale Carlo Poma, Mantova, Italy.
Semin Thromb Hemost. 2011 Feb;37(1):7-10. doi: 10.1055/s-0030-1270065. Epub 2011 Jan 19.
The hemostatic balance is a complex system where the delicate equilibrium is regulated by several factors including hormones. A variety of endocrine disorders have been reported to be associated with coagulation abnormalities, ranging from mild laboratory changes to clinically relevant thrombotic or bleeding manifestations. In this review, we summarize the current knowledge on the main abnormalities of the coagulation and fibrinolytic systems associated with thyroid dysfunctions. Overall, although mostly based on uncontrolled studies, data in the literature suggest that patients with hyperthyroidism or subclinical hypothyroidism have a hypercoagulative state, whereas patients with overt hypothyroidism have a bleeding tendency.
止血平衡是一个复杂的系统，其微妙的平衡由多种因素调节，包括激素。据报道，多种内分泌紊乱与凝血异常有关，从轻微的实验室改变到具有临床相关性的血栓形成或出血表现。在这篇综述中，我们总结了与甲状腺功能障碍相关的凝血和纤维蛋白溶解系统主要异常的现有知识。总的来说，尽管主要基于非对照研究，但文献中的数据表明，甲状腺功能亢进症或亚临床甲状腺功能减退症患者存在高凝状态，而显性甲状腺功能减退症患者则有出血倾向。
