BK病毒诱导的仓鼠肿瘤细胞中的肿瘤特异性移植抗原
Tumour specific transplantation antigen in hamster tumour cells induced with BK virus.
作者信息
Karjalainen H E, Laaksonen A M, Mäntyjärvi R A
出版信息
J Gen Virol. 1978 Oct;41(1):171-4. doi: 10.1099/0022-1317-41-1-171.
PMID:212516
Abstract
Immunization of hamsters with purified BK virus (BKV) followed by transplantation of BKV-induced hamster tumour cells revealed a tumour specific transplantation antigen (TSTA) in these cells. The antigen did not cross-react with the TSTA of SV40 since immunization with BKV did not protect against challenge of SV40 tumour cells.
摘要
用纯化的BK病毒（BKV）免疫仓鼠，然后移植BKV诱导的仓鼠肿瘤细胞，结果显示这些细胞中存在肿瘤特异性移植抗原（TSTA）。该抗原与SV40的TSTA无交叉反应，因为用BKV免疫不能抵御SV40肿瘤细胞的攻击。
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