Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, 28 Yungun-Dong, Chongno-Ku, Seoul 110-744, Republic of Korea.
Eur J Obstet Gynecol Reprod Biol. 2011 May;156(1):87-90. doi: 10.1016/j.ejogrb.2010.12.018. Epub 2011 Jan 19.
To evaluate the relationship between endometriosis and polymorphisms in insulin-like growth factors (IGFs) and IGF-I receptor genes.
In a case-control study, 128 women with endometriosis and 108 control women were recruited at the Department of Obstetrics and Gynecology in Seoul National University Hospital. Determinations of -969(CA) block, -603A>T, and -553T>C single nucleotide polymorphism (SNP)s in the IGF-I gene, c.517C>T, c.540G>T and 820G>A SNPs in the IGF-II gene, and c.3129G>A SNP in the IGF-I receptor gene were performed to evaluate the prevalence of IGFs and IGF-I receptor genotypes or alleles.
Among studied SNPs, the IGF-II 820G>A polymorphism was associated with endometriosis. Women with endometriosis were observed 1.99 times more frequently in the GG genotype of the IGF-II 820G>A polymorphism compared with non-GG genotype (95% confidence level: 1.18-3.35). The similar finding was observed only in early stage endometriosis (stages I and II).
The IGF-II 820G>A polymorphism is a genetic factor which may be associated with the development of endometriosis in Korean women.
评估子宫内膜异位症与胰岛素样生长因子（IGFs）和 IGF-I 受体基因多态性的关系。
在一项病例对照研究中，在首尔国立大学医院妇产科招募了 128 名子宫内膜异位症患者和 108 名对照女性。对 IGF-I 基因的 -969(CA) 块、-603A>T 和 -553T>C 单核苷酸多态性（SNP）、IGF-II 基因的 c.517C>T、c.540G>T 和 820G>A SNPs 以及 IGF-I 受体基因的 c.3129G>A SNP 进行了测定，以评估 IGFs 和 IGF-I 受体基因型或等位基因的发生率。
在所研究的 SNP 中，IGF-II 820G>A 多态性与子宫内膜异位症相关。与非 GG 基因型相比，患有子宫内膜异位症的女性 IGF-II 820G>A 多态性的 GG 基因型更常见 1.99 倍（95%置信水平：1.18-3.35）。仅在早期子宫内膜异位症（I 期和 II 期）中观察到类似的发现。
IGF-II 820G>A 多态性是一个遗传因素，可能与韩国女性子宫内膜异位症的发生有关。
