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[采用牛胸廓内动脉移植物的冠状动脉旁路移植术]

[Coronary artery bypass with bovine internal mammary artery graft].

作者信息

Donzeau-Gouge P, Touati G, Vouhé P R, Roy A, Farge C, Leca F, Neveux J Y

机构信息

Unité de chirurgie thoracique et cardiovasculaire, clinique du Bois de Verrières, Antony.

出版信息

Arch Mal Coeur Vaiss. 1990 Nov;83(12):1811-5.

PMID:2125191
Abstract

Ten of 1,025 patients undergoing coronary bypass surgery received one or two bovine internal mammary artery grafts. Surgery consisted in quadruple coronary bypass in 1 case, triple coronary bypass in 3 cases and double coronary bypass in 6 cases using 4 autologous saphenous vein grafts, 6 autologous internal mammary artery grafts and 13 bovine internal mammary artery grafts. It was necessary to use bovine internal mammary artery grafts because of total bilateral venous stripping in 5 patients, diffuse, bilateral varicose veins in 4 patients and because of the insufficient length of the vein in 1 patient. Short and medium-term (12 months) angiographic studies of the bovine grafts showed 5 occluded grafts, 2 proximal graft stenoses, and 1 patient graft up to the time of his death of extracardiac causes, with a maximum follow-up of 13 months. One of these 10 patients died in the early postoperative period of extracardiac causes with a patent bovine coronary graft. Another patient died in the 5th postoperative month during reoperation motivated by occlusion of the two implanted bovine coronary grafts. The other 8 patients are alive and stable from the coronary view point. Bovine internal mammary artery grafts may be used to manage an acute episode of coronary insufficiency by providing the time for the collateral circulation to develop but it does not provide a complete and durable method of revascularisation. Their use should therefore be reserved for exceptional cases.

摘要

1025例接受冠状动脉搭桥手术的患者中,有10例接受了一根或两根牛的乳内动脉移植物。手术包括1例四重冠状动脉搭桥、3例三重冠状动脉搭桥和6例双重冠状动脉搭桥,使用了4根自体大隐静脉移植物、6根自体乳内动脉移植物和13根牛的乳内动脉移植物。由于5例患者双侧静脉完全剥脱、4例患者双侧弥漫性静脉曲张以及1例患者静脉长度不足,因此有必要使用牛的乳内动脉移植物。对牛移植物进行的短期和中期(12个月)血管造影研究显示,有5根移植物闭塞,2根移植物近端狭窄,1例患者的移植物直至其死于心外原因,最长随访时间为13个月。这10例患者中有1例在术后早期死于心外原因,其牛冠状动脉移植物通畅。另1例患者在术后第5个月再次手术时死亡,原因是植入的两根牛冠状动脉移植物闭塞。从冠状动脉角度来看,其他8例患者存活且病情稳定。牛的乳内动脉移植物可用于在侧支循环形成的时间段内处理冠状动脉供血不足的急性发作,但它并不能提供一种完整且持久的血运重建方法。因此,其使用应仅限于特殊情况。

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