Shimizu H, Uehara Y, Shimomura Y, Negishi M, Fukatsu A
First Department of Internal Medicine, Gunma University Hospital, Maebashi, Japan.
Biochem Biophys Res Commun. 1990 Dec 31;173(3):1280-6. doi: 10.1016/s0006-291x(05)80925-8.
An involvement of prostaglandin synthesis in reduced insulin secretion by interleukin-1 was investigated in adrenalectomized (ADX) rats. The recombinant human interleukin-1 beta (IL-1) significantly reduced insulin secretion in ADX rats 2 and 4 hr after the injection, although IL-1 stimulated insulin secretion in intact rats. In ADX rat, IL-1 showed dose-dependent inhibition of pancreatic insulin secretion. In addition, insulin response to intravenous glucose loading was also attenuated in ADX rats with pretreatment by IL-1. At 4 hours after injection, ibuprofen (IBP; 0.5-50.0 mg/kg, ip), selective cyclooxygenase blocker, attenuated insulin inhibition by IL-1 in a dose-dependent manner. These data suggest that IL-1 may suppress in vivo insulin release at least in part through the mediation of prostaglandin synthesis in the absence of adrenal glands.
在肾上腺切除（ADX）大鼠中研究了前列腺素合成参与白细胞介素-1降低胰岛素分泌的情况。重组人白细胞介素-1β（IL-1）在注射后2小时和4小时显著降低了ADX大鼠的胰岛素分泌，尽管IL-1在完整大鼠中刺激胰岛素分泌。在ADX大鼠中，IL-1对胰腺胰岛素分泌表现出剂量依赖性抑制。此外，在经IL-1预处理的ADX大鼠中，静脉注射葡萄糖负荷后的胰岛素反应也减弱。注射后4小时，选择性环氧化酶阻滞剂布洛芬（IBP；0.5 - 50.0 mg/kg，腹腔注射）以剂量依赖性方式减弱了IL-1对胰岛素的抑制作用。这些数据表明，在没有肾上腺的情况下，IL-1可能至少部分通过前列腺素合成的介导来抑制体内胰岛素释放。
