Gongadze N, Gabunia L, Bakuridze K, Abulashvili D, Makharadze T
Georgian Med News. 2010 Dec(189):40-52.
The review analyzes the possible role of multioscillatory circadian system in the seasonal circadian variability of basic indices of cardiovascular system and probable mechanisms of development of changes in diurnal rhythms of the organism. It was postulated the close relationship between hemodynamic parameters and homeostatic mechanisms of circulation. The destruction of relationship may initiate the development of pathologic condition - desynchronizes. Studies suggest a potential role of relationship between circadian rhythms and secretion of vasoactive peptides, such as angiotensine, endothelins, sodium uretic peptide, endothelial relaxing factor and enkephalins, the circadian rhythmicity of receptor. It is suggested the necessity of investigation of circadian hemodynamic rhythms during desinchronoses formation in purpose of rational pharmacotherapy of different cardiovascular diseases.
该综述分析了多振荡昼夜节律系统在心血管系统基本指标季节性昼夜变化中的可能作用，以及机体昼夜节律变化发展的可能机制。推测了血液动力学参数与循环稳态机制之间的密切关系。这种关系的破坏可能引发病理状况的发展——失同步。研究表明昼夜节律与血管活性肽分泌之间的潜在关系，如血管紧张素、内皮素、钠尿肽、内皮舒张因子和脑啡肽，以及受体的昼夜节律性。建议在失同步形成过程中研究昼夜血液动力学节律，以实现对不同心血管疾病的合理药物治疗。
