高压灭菌和巴氏杀菌对骨愈合负面影响的比较。
The comparison of the negative effect of autoclaving and pasteurization on bone healing.
作者信息
Vural Recep, Akesen Burak, Karakayalı Mehmet, Yalçınkaya Ulviye, Aydınlı Ufuk
机构信息
Faculty of Medicine, Departments of Orthopedics and Traumatology, Uludağ University, Bursa, Turkey.
出版信息
Acta Orthop Traumatol Turc. 2010;44(4):322-7. doi: 10.3944/AOTT.2010.2382.
OBJECTIVES
The aim of this study was to compare the effects of autoclaving and pasteurization on bone healing.
METHODS
Twenty-five full-grown male rabbits were included in the study; all 25 had bone blocks resected and reimplanted. In group 1, bone blocks were autoclaved; in group 2, bone blocks were pasteurized; and in group 3 (controls), resected bone blocks were reimplanted without sterilization.
RESULTS
Heiple scores of the proximal parts of the fusion surfaces in group 1, group 2, and group 3 were 12.8±0.4, 6.8±1.2, and 10.2±1.9, respectively. Heiple scores of the distal parts of the fusion surfaces in group 1, group 2, and group 3 were 10.8±0.8, 6.0±1.1, and 9.8±1.5, respectively. Differences in radiologic scores were not statistically significant between the groups for proximal or distal fusion surfaces at 3 and 6 weeks.
CONCLUSION
In conclusion, pasteurization has a less negative effect on bone healing than autoclaving, and can be considered for bone sterilization in certain circumstances.
目的
本研究旨在比较高压灭菌和巴氏消毒对骨愈合的影响。
方法
25只成年雄性兔子纳入本研究；全部25只均切除并重新植入骨块。第1组骨块进行高压灭菌；第2组骨块进行巴氏消毒；第3组（对照组）切除的骨块未进行灭菌直接重新植入。
结果
第1组、第2组和第3组融合面近端的海普尔评分分别为12.8±0.4、6.8±1.2和10.2±1.9。第1组、第2组和第3组融合面远端的海普尔评分分别为10.8±0.8、6.0±1.1和9.8±1.5。在3周和6周时，各实验组近端或远端融合面的放射学评分差异无统计学意义。
结论
总之，巴氏消毒对骨愈合的负面影响小于高压灭菌，在某些情况下可考虑用于骨灭菌。
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