妊娠期脂代谢异常相关性胰腺炎应用非诺贝特治疗。
Hyperlipidemia-associated pancreatitis in pregnancy managed with fenofibrate.
机构信息
From the Departments of Obstetrics and Gynecology and Maternal Fetal Medicine, William Beaumont Hospital, Royal Oak, Michigan.
出版信息
Obstet Gynecol. 2011 Feb;117(2 Pt 2):517-519. doi: 10.1097/AOG.0b013e31820755b5.
BACKGROUND
Pancreatitis is a concerning clinical event during pregnancy, with high morbidity and mortality rates for mother and fetus. Hypertriglyceridemia is considered a rare cause of pancreatitis in pregnancy, with the majority of reported cases being associated with the lipid metabolism disorders.
CASE
We report on a case of hypertriglyceridemia-induced pancreatitis in a woman presenting at 32 weeks of gestational age. Her dyslipidemia was not controlled with diet alone, necessitating medical intervention. Fenofibrate was used successfully. Recurrence of pancreatitis during the pregnancy was avoided, and a healthy neonate was delivered at 35 weeks of gestation.
CONCLUSION
Fenofibrate was used safely and successfully during pregnancy in this case of hypertriglyceridemia-associated pancreatitis refractory to conservative measures.
背景
胰腺炎是妊娠期间令人担忧的临床事件，母亲和胎儿的发病率和死亡率都很高。高甘油三酯血症被认为是妊娠相关性胰腺炎的罕见病因，大多数报道的病例与脂代谢紊乱有关。
病例
我们报告了一例在 32 孕周出现的高甘油三酯血症相关性胰腺炎的病例。她的血脂异常不能仅通过饮食控制，需要进行药物干预。非诺贝特治疗取得了成功。在妊娠期间，胰腺炎未再复发，并于 35 孕周时成功分娩出健康的新生儿。
结论
在这例对保守治疗无效的高甘油三酯血症相关性胰腺炎病例中，非诺贝特在妊娠期间安全且有效地得到了应用。
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