Flossdorf T, Breulmann M, Hopf H B
Abteilung für Klinische Anaesthesiologie, Zentrum für Anaesthesiologie Heinrich-Heine-Universität, Düsseldorf, FRG.
Intensive Care Med. 1990;16(7):454-6. doi: 10.1007/BF01711225.
We report a patient with massive pulmonary embolism and circulatory shock during pregnancy (31st gestational week) and preterm labour who has been successfully treated with recombinant tissue type plasminogen activator. Thrombolysis was performed using 10 mg.h-1 over 4 h followed by 2 mg.h-1 for 1 h 30 min resulting in complete resolution of cardio-respiratory symptoms. Except for slight bleeding from one puncture site no complications occurred. At 48 h after the end of thrombolytic therapy the patient was delivered spontaneously of a male preterm healthy infant. The relevance of this new thrombolytic agent in the treatment of massive life-threatening pulmonary embolism during pregnancy is discussed.
我们报告了一名在妊娠期间（孕31周）发生大面积肺栓塞和循环性休克并伴有早产的患者，该患者接受重组组织型纤溶酶原激活剂治疗成功。溶栓治疗采用4小时内10mg/h的速度给药，随后1小时30分钟内以2mg/h的速度给药，结果心肺症状完全缓解。除一个穿刺部位有轻微出血外，未发生其他并发症。溶栓治疗结束后48小时，患者自然分娩出一名健康的早产男婴。本文讨论了这种新型溶栓剂在治疗妊娠期间危及生命的大面积肺栓塞中的相关性。
