• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在小鼠乳腺肿瘤病毒启动子处，高效的核心启动子功能需要组蛋白去乙酰化酶（HDAC）活性。

HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter.

作者信息

Lee Sang C, Magklara Angeliki, Smith Catharine L

机构信息

Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 E. Mabel Street, Tucson, AZ 85721-0207, USA.

出版信息

J Biomed Biotechnol. 2011;2011:416905. doi: 10.1155/2011/416905. Epub 2010 Dec 26.

DOI:10.1155/2011/416905
PMID:21253530
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3021843/
Abstract

Histone deacetylases (HDACs) have been shown to be required for basal or inducible transcription at a variety of genes by poorly understood mechanisms. We demonstrated previously that HDAC inhibition rapidly repressed transcription from the mouse mammary tumor virus (MMTV) promoter by a mechanism that does not require the binding of upstream transcription factors. In the current study, we find that HDACs work through the core promoter sequences of MMTV as well as those of several cellular genes to facilitate transcriptional initiation through deacetylation of nonhistone proteins.

摘要

组蛋白去乙酰化酶（HDACs）已被证明通过尚不明确的机制参与多种基因的基础转录或诱导转录。我们之前证实，HDAC抑制可通过一种不依赖上游转录因子结合的机制迅速抑制小鼠乳腺肿瘤病毒（MMTV）启动子的转录。在本研究中，我们发现HDACs通过MMTV的核心启动子序列以及几个细胞基因的核心启动子序列发挥作用，通过使非组蛋白去乙酰化来促进转录起始。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/a299abb545a9/JBB2011-416905.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/38751baafc75/JBB2011-416905.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/902b7b5a51e8/JBB2011-416905.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/9a69a6711d83/JBB2011-416905.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/1185e93f056d/JBB2011-416905.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/382a2b330052/JBB2011-416905.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/178e92318671/JBB2011-416905.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/8be33bf444fa/JBB2011-416905.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/a299abb545a9/JBB2011-416905.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/38751baafc75/JBB2011-416905.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/902b7b5a51e8/JBB2011-416905.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/9a69a6711d83/JBB2011-416905.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/1185e93f056d/JBB2011-416905.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/382a2b330052/JBB2011-416905.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/178e92318671/JBB2011-416905.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/8be33bf444fa/JBB2011-416905.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3e/3021843/a299abb545a9/JBB2011-416905.008.jpg

相似文献

1
HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter.在小鼠乳腺肿瘤病毒启动子处，高效的核心启动子功能需要组蛋白去乙酰化酶（HDAC）活性。
J Biomed Biotechnol. 2011;2011:416905. doi: 10.1155/2011/416905. Epub 2010 Dec 26.
2
Inhibition of MMTV transcription by HDAC inhibitors occurs independent of changes in chromatin remodeling and increased histone acetylation.组蛋白去乙酰化酶抑制剂对小鼠乳腺肿瘤病毒转录的抑制作用独立于染色质重塑的变化和组蛋白乙酰化的增加而发生。
Oncogene. 2003 Jul 31;22(31):4807-18. doi: 10.1038/sj.onc.1206722.
3
Dynamic histone acetylation/deacetylation with progesterone receptor-mediated transcription.孕酮受体介导转录过程中的动态组蛋白乙酰化/去乙酰化
Mol Endocrinol. 2007 Apr;21(4):843-56. doi: 10.1210/me.2006-0244. Epub 2007 Jan 16.
4
Role of the TATA box in transcription of the mouse mammary tumor virus long terminal repeat.TATA 框在小鼠乳腺肿瘤病毒长末端重复序列转录中的作用。
Mol Endocrinol. 1995 Sep;9(9):1180-92. doi: 10.1210/mend.9.9.7491110.
5
Inhibition of histone deacetylation augments dihydrotestosterone induction of androgen receptor levels: an explanation for trichostatin A effects on androgen-induced chromatin remodeling and transcription of the mouse mammary tumor virus promoter.组蛋白去乙酰化的抑制增强了二氢睾酮对雄激素受体水平的诱导作用：对曲古抑菌素A影响雄激素诱导的染色质重塑及小鼠乳腺肿瘤病毒启动子转录的一种解释。
Exp Cell Res. 1999 Nov 1;252(2):471-8. doi: 10.1006/excr.1999.4638.
6
The histone deacetylase inhibitor trichostatin A blocks progesterone receptor-mediated transactivation of the mouse mammary tumor virus promoter in vivo.组蛋白脱乙酰酶抑制剂曲古抑菌素A在体内可阻断孕激素受体介导的小鼠乳腺肿瘤病毒启动子的反式激活。
J Biol Chem. 2002 Apr 26;277(17):15171-81. doi: 10.1074/jbc.M200349200. Epub 2002 Jan 30.
7
Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2.组蛋白脱乙酰酶抑制剂可抑制c-Jun及其靶基因（包括COX-2）的诱导。
J Biol Chem. 2005 Sep 23;280(38):32569-77. doi: 10.1074/jbc.M503201200. Epub 2005 Jul 1.
8
Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex.组蛋白去乙酰化酶-mSin3A复合物对人促黄体生成素受体基因转录的沉默作用。
J Biol Chem. 2002 Sep 6;277(36):33431-8. doi: 10.1074/jbc.M204417200. Epub 2002 Jun 28.
9
Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension.组蛋白去乙酰化酶的抑制作用可降低NADPH氧化酶的转录和活性氧的产生，并改善肺动脉高压。
Free Radic Biol Med. 2016 Oct;99:167-178. doi: 10.1016/j.freeradbiomed.2016.08.003. Epub 2016 Aug 3.
10
Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene.mSin3A-组蛋白去乙酰化酶1/2共抑制复合物与小鼠类固醇生成急性调节蛋白基因的关联。
Mol Endocrinol. 2006 Jan;20(1):100-13. doi: 10.1210/me.2004-0495. Epub 2005 Aug 18.

引用本文的文献

1
Minireview: The versatile roles of lysine deacetylases in steroid receptor signaling.综述：赖氨酸脱乙酰酶在类固醇受体信号传导中的多种作用
Mol Endocrinol. 2014 May;28(5):607-21. doi: 10.1210/me.2014-1002. Epub 2014 Mar 19.
2
Visualizing epigenetics: current advances and advantages in HDAC PET imaging techniques.可视化表观遗传学：HDAC正电子发射断层扫描成像技术的当前进展与优势
Neuroscience. 2014 Apr 4;264:186-97. doi: 10.1016/j.neuroscience.2013.09.018. Epub 2013 Sep 17.
3
Class I lysine deacetylases facilitate glucocorticoid-induced transcription.

本文引用的文献

1
The human Mediator complex: a versatile, genome-wide regulator of transcription.人类中介体复合物：一种通用的、全基因组转录调控因子。
Trends Biochem Sci. 2010 Jun;35(6):315-22. doi: 10.1016/j.tibs.2010.02.004. Epub 2010 Mar 17.
2
Histone deacetylase inhibitors: keeping momentum for neuromuscular and cardiovascular diseases treatment.组蛋白去乙酰化酶抑制剂：在神经肌肉和心血管疾病治疗方面保持发展势头。
Pharmacol Res. 2010 Jul;62(1):3-10. doi: 10.1016/j.phrs.2010.02.014. Epub 2010 Mar 19.
3
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes.
I 类赖氨酸去乙酰化酶促进糖皮质激素诱导的转录。
J Biol Chem. 2013 Oct 4;288(40):28900-12. doi: 10.1074/jbc.M113.505115. Epub 2013 Aug 14.
4
Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors.组蛋白去乙酰化酶在表观遗传调控中的作用：抑制剂研究中的新范例。
Clin Epigenetics. 2012 Mar 12;4(1):5. doi: 10.1186/1868-7083-4-5.
全基因组范围内对组蛋白乙酰转移酶（HATs）和组蛋白去乙酰化酶（HDACs）的图谱绘制揭示了它们在活跃基因和非活跃基因中的不同功能。
Cell. 2009 Sep 4;138(5):1019-31. doi: 10.1016/j.cell.2009.06.049. Epub 2009 Aug 20.
4
Regulation of gene expression via the core promoter and the basal transcriptional machinery.通过核心启动子和基础转录机制调控基因表达。
Dev Biol. 2010 Mar 15;339(2):225-9. doi: 10.1016/j.ydbio.2009.08.009. Epub 2009 Aug 13.
5
Histone deacetylase inhibitors in inflammatory disease.组蛋白去乙酰化酶抑制剂在炎症性疾病中的作用
Curr Top Med Chem. 2009;9(3):309-19. doi: 10.2174/156802609788085250.
6
Inhibition of histone deacetylases: a pharmacological approach to the treatment of non-cancer disorders.组蛋白去乙酰化酶的抑制作用：一种治疗非癌症疾病的药理学方法。
Curr Top Med Chem. 2009;9(3):257-71. doi: 10.2174/156802609788085241.
7
Isoform-specific histone deacetylase inhibitors: the next step?亚型特异性组蛋白去乙酰化酶抑制剂：下一步何去何从？
Cancer Lett. 2009 Aug 8;280(2):211-21. doi: 10.1016/j.canlet.2009.02.013. Epub 2009 Mar 16.
8
The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.人类CDK8亚复合物是一种控制中介体共激活因子功能的分子开关。
Genes Dev. 2009 Feb 15;23(4):439-51. doi: 10.1101/gad.1767009.
9
Development of vorinostat: current applications and future perspectives for cancer therapy.伏立诺他的研发：癌症治疗的当前应用及未来展望
Cancer Lett. 2009 Aug 8;280(2):201-10. doi: 10.1016/j.canlet.2009.01.002. Epub 2009 Jan 31.
10
The many roles of histone deacetylases in development and physiology: implications for disease and therapy.组蛋白去乙酰化酶在发育和生理学中的多种作用：对疾病和治疗的影响。
Nat Rev Genet. 2009 Jan;10(1):32-42. doi: 10.1038/nrg2485.