Aarts E O, Berends F J, Janssen I M C, Schweitzer D H
Department of Bariatric Surgery, Rijnstate Hospital, Alysis Zorggroep, P.O. box 9555, 6800 TA Arnhem, The Netherlands.
J Obes. 2011;2011:156164. doi: 10.1155/2011/156164. Epub 2010 Dec 26.
Background. Calcium malabsorption after bariatric surgery may be harmful to skeletal health and demands for optimal skeletal management. Methods. 103 Patients were evaluated retrospectively at 12 months after surgery. The evaluation included a questionnaire about stool frequency and consistency and laboratory assessments. Results. 103 Patients, 27 males and 76 females, were included in the study. 83 Patients had an alimentary limb of 100 cm and 20 patients one of 150 cm. At 12 months after surgery, 77.7% reported changes of bowel habits, albumin adjusted calcium levels were normal in all but 2 patients, and PTH levels were increased in 35%. Correlations between semiquantified bowel scores (fecal scores) and data from the laboratory demonstrated increasing PTH values along with more frequent and softer/watery stools (RR 30.5, CI 6.2-149.2, P < .001). There was a trend for higher PTH levels in patients with an alimentary limb of 150 cm. Normal PTH levels were more frequently found in case of calcium and vitamin D3 use (RR 14.3, CI 3.6-56.5, P < .001). Conclusion. This study demonstrates interrelationships between semi-quantified fecal scores, PTH levels, and the compliance of taking calcium/vitamin D3 suppletion. However, prospective randomized studies are necessary to show causal relationships.
背景。减肥手术后钙吸收不良可能对骨骼健康有害,需要进行最佳的骨骼管理。方法。对103例患者在术后12个月进行回顾性评估。评估包括一份关于大便频率和稠度的问卷以及实验室检查。结果。本研究纳入了103例患者,其中男性27例,女性76例。83例患者的消化道肠袢长度为100 cm,20例患者的为150 cm。术后12个月时,77.7%的患者报告有排便习惯改变,除2例患者外,所有患者的白蛋白校正钙水平均正常,35%的患者甲状旁腺激素(PTH)水平升高。半定量肠道评分(粪便评分)与实验室数据之间的相关性表明,PTH值随着排便频率增加以及大便更稀/呈水样而升高(相对风险30.5,可信区间6.2 - 149.2,P < .001)。消化道肠袢长度为150 cm的患者有PTH水平较高的趋势。在使用钙和维生素D3的情况下,更常发现PTH水平正常(相对风险14.3,可信区间3.6 - 56.5,P < .001)。结论。本研究证明了半定量粪便评分、PTH水平以及服用钙/维生素D3补充剂的依从性之间的相互关系。然而,需要进行前瞻性随机研究来证实因果关系。