抗谷氨酸脱羧酶抗体阳性的格雷夫斯病患者1型糖尿病的发生：一项8年随访研究。
Occurrence of type 1 diabetes in graves' disease patients who are positive for antiglutamic Acid decarboxylase antibodies: an 8-year followup study.
作者信息
Taniyama Matsuo, Kasuga Akira, Nagayama Chieko, Ito Koichi
机构信息
Division of Endocrinology & Metabolism, Department of Internal Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa 227-8501, Japan.
出版信息
J Thyroid Res. 2010 Dec 28;2011:306487. doi: 10.4061/2011/306487.
Abstract
Glutamic acid decarboxylase antibodies (GADAs) are one of the markers of islet cell autoimmunity and are sometimes present before the onset of type 1 diabetes (T1D). GADA can be present in Graves' patients without diabetes; however, the outcome of GADA-positive Graves' patients is not fully understood, and the predictive value of GADA for the development of T1D in Graves' patients remains to be clarified. We investigated the prevalence of GADA in 158 patients with Graves' disease and detected GADA in 10 patients. They were followed up to discover whether or not T1D developed. In the course of eight years, 2 patients with high titers of GADA developed T1D, both had long-standing antithyroid drug-resistant Graves' disease. Thus, Graves' disease with high GADA titer seems to be at high risk for T1D.
摘要
谷氨酸脱羧酶抗体（GADA）是胰岛细胞自身免疫的标志物之一，有时在1型糖尿病（T1D）发病前就已存在。GADA可出现在无糖尿病的格雷夫斯病患者中；然而，GADA阳性的格雷夫斯病患者的结局尚未完全明确，GADA对格雷夫斯病患者发生T1D的预测价值仍有待阐明。我们调查了158例格雷夫斯病患者中GADA的患病率，发现10例患者存在GADA。对他们进行随访以观察是否发生T1D。在8年的随访过程中，2例GADA高滴度的患者发生了T1D，二者均患有长期抗甲状腺药物抵抗的格雷夫斯病。因此，GADA滴度高的格雷夫斯病似乎发生T1D的风险较高。
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