电化学方法用于检测 DNA 甲基化和测定甲基转移酶活性。

An electrochemical approach for detection of DNA methylation and assay of the methyltransferase activity.

机构信息

Jiangsu Key Laboratory of Power Batteries, Laboratory of Electrochemistry, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China.

出版信息

Chem Commun (Camb). 2011 Mar 14;47(10):2844-6. doi: 10.1039/c0cc05153e. Epub 2011 Jan 21.

DOI:10.1039/c0cc05153e

PMID:21253634

Abstract

This work develops an electrochemical approach for rapid detection of the genomic DNA methylation level, assay of methyltransferase activity, and evaluation and screening of the inhibitors of methyltransferase. This method may be a help for the discovery of anticancer drugs.

摘要

本工作开发了一种电化学方法，用于快速检测基因组 DNA 甲基化水平、测定甲基转移酶活性、评估和筛选甲基转移酶抑制剂。该方法可能有助于抗癌药物的发现。