WHO Collaborating Centre for Drug Information, National Poison Centre, Universiti Sains Malaysia (USM), Penang, Malaysia.
Pharmacoepidemiol Drug Saf. 2011 Feb;20(2):203-8. doi: 10.1002/pds.2060. Epub 2010 Dec 23.
Acetaminophen overdose may be accompanied by electrolyte disturbances. The basis for electrolyte change appears to be due to increased fractional urinary electrolyte excretion.
This study investigated the impact of serum acetaminophen concentration on changes in serum potassium, creatinine and urea concentrations in patients with acetaminophen overdose.
This was a retrospective cohort study which included patients admitted to the emergency department and hospital within 24 h of acetaminophen ingestion. The study was conducted over a period of 5 years from 1 January 2004 to 31 December 2008. Data are presented as mean ± SD and as medians (interquartile range) and groups were compared using independent two-tailed Student t-test. Statistical Package for Social Sciences (SPSS) 15 was used for data analysis.
Two hundred and eighty-three patients were studied (44 males and 239 females), mean age 23 ± 7.5 years. Patients who had a serum acetaminophen concentration above a 'possible toxicity' treatment line were associated with an elevation in serum creatinine concentration (p=0.044) and a reduction in the serum potassium concentration (p<0.001) but were not associated with a reduction in serum urea concentration (p>0.99). During the study period, 63.3% (179 patients) had serum potassium concentrations less than the normal concentration (3.5 mmol/l) and 31.4% (89 patients) had serum urea concentrations less than the normal concentration (2.5 mmol/l). The serum creatinine concentration in all patients was within the normal range.
Acetaminophen appears to cause a concentration-dependent reduction of potassium concentrations and an elevation of creatinine concentrations of short duration (<24 h) after overdose.
对乙酰氨基酚过量可能伴有电解质紊乱。电解质变化的基础似乎是由于尿电解质排泄分数增加。
本研究调查了血清对乙酰氨基酚浓度对乙酰氨基酚过量患者血清钾、肌酐和尿素浓度变化的影响。
这是一项回顾性队列研究，纳入了在对乙酰氨基酚摄入后 24 小时内入住急诊科和医院的患者。该研究于 2004 年 1 月 1 日至 2008 年 12 月 31 日期间进行了 5 年。数据以平均值±标准差和中位数（四分位数间距）表示，并使用独立的双尾学生 t 检验比较组间差异。采用统计软件包社会科学（SPSS）15 进行数据分析。
共研究了 283 例患者（44 例男性和 239 例女性），平均年龄 23 ± 7.5 岁。血清对乙酰氨基酚浓度高于“可能有毒性”治疗线的患者，其血清肌酐浓度升高（p=0.044），血清钾浓度降低（p<0.001），但血清尿素浓度降低（p>0.99）。在研究期间，63.3%（179 例）的患者血清钾浓度低于正常浓度（3.5mmol/l），31.4%（89 例）的患者血清尿素浓度低于正常浓度（2.5mmol/l）。所有患者的血清肌酐浓度均在正常范围内。
对乙酰氨基酚似乎会导致钾浓度的浓度依赖性降低，并在过量后短时间内（<24 小时）导致肌酐浓度升高。
