Natochin Iu V
Ross Fiziol Zh Im I M Sechenova. 2010 Sep;96(9):906-23.
Progress of physiology is closely connected with achievements of the adjacent sciences that developed particularly intensively at the end of the XX century. The key role in strategy of physiological investigations is played by study of the nature of regulation of individual processes providing activity of the organism as a whole. By the example of study of renal function there are discussed the issue of integration of its incretory and secretory functions, elucidation of the mechanism of activity of regulatory systems with taking into account the wide diversity of types and subtypes of receptors, interaction of numerous variants of cotransporters, pumps, water and ion channels, which eventually provides the amazing efficiency of the coordinated work of several organs and systems for stabilization of physical-chemical parameters of the internal environment. Development of physiology is of importance for progress of natural science and clinical medicine, as its achievements facilitate discovery of mechanisms of physiological functions, elucidation of defect of the locus underlying dysfunction.
生理学的进展与相邻学科的成就密切相关，这些学科在20世纪末得到了特别迅猛的发展。在生理学研究策略中，关键作用在于对调节个体过程本质的研究，这些过程维持着整个机体的活动。以肾功能研究为例，探讨了其分泌和排泄功能的整合问题，阐明了调节系统的活动机制，同时考虑到受体类型和亚型的广泛多样性、多种共转运体、泵、水和离子通道变体之间的相互作用，这些最终使得多个器官和系统协同工作，以惊人的效率稳定内环境的物理化学参数。生理学的发展对自然科学和临床医学的进步至关重要，因为其成果有助于发现生理功能的机制，阐明功能障碍背后位点的缺陷。
